![]() ![]() BUN-to-creatinine ratio (the ratio of blood urea nitrogen to creatinine) can indicate other problems besides those intrinsic to the kidney for example, a urea concentration raised out of proportion to the creatinine may indicate a prerenal problem such as volume depletion.Ĭounterintuitively, supporting the observation of higher creatinine production in women compared to men, and putting into question the algorithms for GFR that do not distinguish for sex accordingly, women have higher muscle protein synthesis and higher muscle protein turnover across the life span. Īn alternative estimation of kidney function can be made when interpreting the blood plasma concentration of creatinine along with that of urea. (In the absence of secretion, creatinine behaves like inulin). ![]() Ketoacids, cimetidine, and trimethoprim reduce creatinine tubular secretion and, therefore, increase the accuracy of the GFR estimate, in particular in severe kidney dysfunction. In cases of severe kidney dysfunction, though, the CrCl rate will overestimate the GFR because hypersecretion of creatinine by the proximal tubules will account for a larger fraction of the total creatinine cleared. The GFR is clinically important as a measurement of kidney function. Blood creatinine concentrations may also be used alone to calculate the estimated GFR (eGFR). Therefore, creatinine concentrations in blood and urine may be used to calculate the creatinine clearance (CrCl), which correlates approximately with the glomerular filtration rate (GFR). If the filtration in the kidney is deficient, blood creatinine concentrations rise. Little or no tubular reabsorption of creatinine occurs. Ĭreatinine is removed from the blood chiefly by the kidneys, primarily by glomerular filtration, but also by proximal tubular secretion. Creatine conversion to phosphocreatine is catalyzed by creatine kinase spontaneous formation of creatinine occurs during the reaction. It is then transported through blood to the other organs, muscle, and brain, where, through phosphorylation, it becomes the high-energy compound phosphocreatine. Creatinine itself is produced via a biological system involving creatine, phosphocreatine (also known as creatine phosphate), and adenosine triphosphate (ATP, the body's immediate energy supply).Ĭreatine is synthesized primarily in the liver from the methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids arginine and glycine) by S-adenosyl methionine. Serum creatinine (a blood measurement) is an important indicator of kidney health, because it is an easily measured byproduct of muscle metabolism that is excreted unchanged by the kidneys. It is released at a constant rate by the body (depending on muscle mass). This can also help to slow the progression of kidney disease.Creatinine ( / k r i ˈ æ t ɪ n ɪ n, - n iː n/ from Ancient Greek: κρέας (kréas) 'flesh') is a breakdown product of creatine phosphate from muscle and protein metabolism. For overall healthy kidney ensure that you keep your cholesterol, sodium, potassium, and protein in check. A normal level is important to avoid kidney related diseases. ![]() To maintain a normal BUN: Cr ratio you may have to take medication or to alter your diet. The normal ratio range for the BUN to creatinine is commonly between 10:1 and 20:1. You can also use some treatment like salvia and WH30+ to treat renal failure and reduce creatine levels.Drink ginger- it can help remove urea in the blood.Treatment for an Elevated BUN Creatinine Ratio may Include: Itching and Swelling (in the extremities).Lower Growth Hormone- Usually, growth hormones can inhibit urea synthesisĪ high BUN to creatinine ratio is mostly associated with the following symptoms:.Thyroid Abnormalities – They cause abnormal kidney function.In case you have a BUN Creatinine ratio 22, you may be just fine as it is barely above the normal range.Īn Increase in the BUN: Cr Levels May be Caused by For instance, is you have a BUN Creatinine ratio 24, it means you could be slightly dehydrating. An increase in this ratio can result due to a decrease in the flow of blood to the kidneys. Exercises can also increase muscle massĪ high BUN: Cr ratio is the level above 20:1.Avoid drinking alcohol- Alcohol can negatively affect the way your liver functions.Avoid drinking too much water- This can reduce creatine levels.Proper diet- consume foods with enough proteins, fruits, and vegetables.You can Elevate a low BUN: Cr Ratio Levels by: Anabolic Steroids- They decrease protein breakdown.Pregnancy – As a result of increased plasma volume. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |